Antidiabetic Effect of an Active Components Group from Ilex kudingcha and Its Chemical Composition

The leaves of Ilex kudingcha are used as an ethnomedicine in the treatment of symptoms related with diabetes mellitus and obesity throughout the centuries in China. The present study investigated the antidiabetic activities of an active components group (ACG) obtained from Ilex kudingcha in alloxan-induced type 2 diabetic mice. ACG significantly reduced the elevated levels of serum glycaemic and lipids in type 2 diabetic mice. 3-Hydroxy-3-methylglutaryl coenzyme A reductase and glucokinase were upregulated significantly, while fatty acid synthetase, glucose-6-phosphatase catalytic enzyme was downregulated in diabetic mice after treatment of ACG. These findings clearly provided evidences regarding the antidiabetic potentials of ACG from Ilex kudingcha. Using LC-DAD/HR-ESI-TOF-MS, six major components were identified in ACG. They are three dicaffeoylquinic acids that have been reported previously, and three new triterpenoid saponins, which were the first time to be identified in Ilex kudingcha. It is reasonable to assume that antidiabetic activity of Ilex kudingcha against hyperglycemia resulted from these six major components. Also, synergistic effects among their compounds may exist in the antidiabetic activity of Ilex kudingcha

Recipe for single-pair-Weyl-points phonons carrying the same chiral charges

Recently, Wang et al. [Phys. Rev. B, 106, 195129 (2022)] challenged a widely held belief in the field of Weyl physics, demonstrating that single-pair-Weyl-points (SP-WPs) can exist in nonmagnetic spinless systems, contrary to previous assumptions that they could only exist in magnetic systems. Wang et al. observed that the SP-WPs with opposite and even chiral charges (i.e., |C| = 2 or 4) could also exist in nonmagnetic spinless systems. In this Letter, we present a novel finding in which SP-WPs have a partner, namely a charged nodal surface, in nonmagnetic spinless systems. In contrast to previous observations, we show that the SP-WPs can have uneven chiral charges (i.e., |C| = 1). We identify 6 (out of 230) space groups (SGs) that contain such SP-WPs by searching the encyclopedia of emergent particles in three-dimensional crystals. Our finds were confirmed through the phonon spectra of two specific materials Zr3O (with SG 182) and NaPH2NO3 (with SG 173). This discovery broadens the range of materials that can host SP-WPs and applies to other nonmagnetic spinless crystals

Genuine Dirac half-metal: A 2D d0-type ferromagnet Mg4N4

When the spin-orbit coupling (SOC) is absent, almost all the proposed half-metals with the twofold degenerate nodal points at the K (or K') in two-dimensional (2D) materials are misclassified as "Dirac half-metals" owing to the way graphene was utilized in the earliest studies. Actually, each band crossing point at K or K' is described by a 2D Weyl Hamiltonian with definite chirality; hence, it must be a Weyl point. To the best of our knowledge, there have been no reports of a genuine (i.e., fourfold degenerate) Dirac point half-metal in 2D yet. In this Letter, we proposed for the first time that the 2D d0-type ferromagnet Mg4N4 is a genuine Dirac half-metal with a fourfold degenerate Dirac point at the S high-symmetry point, intrinsic magnetism, high Curie temperature, 100% spin-polarization, robustness to the SOC and uniaxial and biaxial strains, and 100% spin-polarized edge states. The work can be seen as a starting point for future predictions of intrinsically magnetic materials with genuine Dirac points, which will aid the frontier of topo-spintronics researchers

Magnetic Weyl and quadratic nodal lines in inverse-Heusler-based fully compensated ferrimagnetic half-metals

Heusler alloys, a class of easily prepared, highly ordered intermetallic compounds, were first reported in 1903. Since then, Heusler alloys have presented various physical phenomena in modern condensed-matter physics. Among Heusler alloys, Heusler-based fully compensated ferrimagnetic half-metals (FCF-HMs) are, particularly, relevant because they host fully spin polarization and have no net magnetic moment, making them have no stray field and less affected by external magnetic fields. Based on first-principles calculations and a tight-binding Hamiltonian model, we provide new insight into inverse-Heusler-based (IHB) FCF-HMs and reveal that they exhibit spin-polarized Weyl and quadratic nodal lines as well as spin-polarized drumheadlike surface states. This paper presents the electron-filling-based design rule and material candidates for IHB FCF-HMs and suggests that IHB FCF-HMs are promising candidates for follow-up investigations in the field of topological spintronics. Subsequent experimental confirmation of the topological states in IHB FCF-HMs is imminent

Dirac point phonons at high-symmetry points: Towards materials realization

Dirac point semimetals and related Fermi arc surface states are extremely important in topological electronic systems. In 2021, Chen et al. [Phy. Rev. Lett. 126, 185301 (2021)10.1103/PhysRevLett.126.185301] proposed that Dirac points can appear on high-symmetry lines (HSLs) or at high-symmetry points (HSPs) in three-dimensional (3D) phonon systems as an extension from Dirac points in electronic systems. Inspired by this work, we present an exhaustive list of Dirac point phonons (DPPs) at HSPs in 230 space groups (SGs) by checking the encyclopedia of emergent particles in 3D crystals. The DPPs are divided into four categories: charge-zero (C-0) DPPs, charge-two (C-2) DPPs, quadratic DPPs (QDPPs), and cubic crossing DPPs (CCDPPs). 29 SGs, 6 SGs, 19 SGs, and 5 SGs are identified as candidate SGs for obtaining C-0 DPPs, C-2 DPPs, QDPPs, and CCDPPs at HSPs, respectively. Importantly, herein we contribute to the realization of materials with DPPs at HSPs and through the following: (i) we propose five realistic materials, namely, Pna21-type Li3AsS3, P21-type NiSbS, P4¯21c-type NaBH4, and Pm3¯n-type Ti3Au and Ta3Sn as materials with C-0 DPPs, C-2 DPPs, QDPPs, and CCDPPs at HSPs, respectively, based on the first-principles calculations. The surface states for these five materials are also examined in this work. (ii) We present 626 candidates with C-0 DPPs, 183 candidates with C-2 DPPs, 433 candidates with QDPPs, and 102 candidates with CCDPPs at HSPs, which were discovered by checking the phonon dispersions of 10 037 materials listed in the phonon database at Kyoto University. (iii) Due to the materials with SGs 103, 104, 106, 158, 184, 222, 223, 226, and 228 are not included in the phonon database at Kyoto University, we propose 18 candidates with C-0 DPPs, 5 candidates with QDPPs, and 8 candidates with CCDPPs at HSPs with above-mentioned SGs by screening the Inorganic Crystal Structure Database (ICSD). Therefore, our findings can be used to guide research into Dirac points at HSPs in 3D phonon systems

Maximally charged single-pair multi-Weyl point phonons in P23 -type BeH2

The realization of multi-Weyl systems with the minimum nonzero number of Weyl points and the maximum charge number remains challenging in topology physics. In this work, based on first-principles calculations, we propose that BeH2 is thermodynamically, mechanically, and dynamically stable in a cubic crystal structure with the P23 space group. Importantly, this is the first work to report the appearance of single-pair multi-Weyl point phonons with the maximum charge number in P23-type BeH2. Furthermore, the number and charge of the Weyl points and the phononic surface modes can be tuned by applying 1% and 2% uniaxial strains along the [100] and [111] directions, respectively. Finally, we report that clean charge-two single-pair triple-point phonons appear in P23-type BeH2 and investigate the related chiral phonon transition under the uniaxial strains

Antiferromagnetic second-order topology in two-dimensional NiRuCl6

In recent years, 2D second-order topological insulators (SOTIs) have garnered considerable interest because of their unique properties. However, only the FeSe monolayer with four corner states (two occupied and two unoccupied states) near the Fermi level has been reported to be a candidate for 2D intrinsic antiferromagnetic SOTIs in theory. The limited amount of antiferromagnetic SOTIs has hindered future research, and corner states should be at the Fermi level in order to manifest interesting physics. Herein, we propose NiRuCl6 as a candidate for 2D antiferromagnetic SOTIs with corner states strictly at the Fermi level. Without spin-orbit coupling (SOC), NiRuCl6 is an antiferromagnetic half-metal with a compensating magnetic moment and decoupled spin bands. In the spin-up channel, NiRuCl6 hosts a nontrivial gap of 1.11 eV, where zero-dimensional corner states appear. In the spin-down channels, NiRuCl6 hosts metallically behaved bands, where a spin-polarized quadratic Weyl point emerges. With SOC, two spin bands are coupled, and NiRuCl6 becomes an antiferromagnetic SOTI with three degenerate corner states at the Fermi level inside the SOC-induced gap with a value of 0.11 eV. Remarkably, the corner states in NiRuCl6 are resistant to changes in SOC strength and magnetization orientation. We also reveal that the phononic second-order topology and corner vibrational modes appear in the phonon dispersion curves of NiRuCl6. The presented results improve the general understanding of antiferromagnetic SOTIs and contribute to the prediction of materials with ideal corner states at the Fermi level, thereby advancing the field of topological antiferromagnetic spintronics

Socioeconomic and Environmental Impacts on Regional Tourism across Chinese Cities: A Spatiotemporal Heterogeneous Perspective

Understanding geospatial impacts of multi-sourced drivers on the tourism industry is of great significance for formulating tourism development policies tailored to regional-specific needs. To date, no research in China has explored the combined impacts of socioeconomic and environmental drivers on city-level tourism from a spatiotemporal heterogeneous perspective. We collected the total tourism revenue indicator and 30 potential influencing factors from 343 cities across China during 2008–2017. Three mainstream regressions and an emerging local spatiotemporal regression named the Bayesian spatiotemporally varying coefficients (Bayesian STVC) model were constructed to investigate the global-scale stationary and local-scale spatiotemporal nonstationary relationships between city-level tourism and various vital drivers. The Bayesian STVC model achieved the best model performance. Globally, eight socioeconomic and environmental factors, average wage (coefficient: 0.47, 95% credible intervals: 0.43–0.51), employed population (−0.14, −0.17–−0.11), GDP per capita (0.47, 0.42–0.52), population density (0.21, 0.16–0.27), night-time light index (−0.01, −0.08–0.05), slope (0.10, 0.06–0.14), vegetation index (0.66, 0.63–0.70), and road network density (0.34, 0.29–0.38), were identified to have nonlinear effects on tourism. Temporally, the main drivers might have gradually changed from the local macro-economic level, population density, and natural environment conditions to the individual economic level over the last decade. Spatially, city-specific dynamic maps of tourism development and geographically clustered influencing maps for eight drivers were produced. In 2017, China formed four significant city-level tourism industry clusters (hot spots, 90% confidence), the locations of which coincide with China’s top four urban agglomerations. Our local spatiotemporal analysis framework for geographical tourism data is expected to provide insights into adjusting regional measures to local conditions and temporal variations in broader social and natural sciences

Coexistence of magnetic and phononic second-order topological phases in two-dimensional NiZrCl6

Second-order topological phases (SOTPs) in two-dimensional (2D) magnetic and phononic systems are rarely reported. In this Letter, using first-principles calculations, we propose that the NiZrCl6 monolayer with space group P312 (No. 149) is a 2D ferromagnetic material with rich SOTPs: (i) magnetic SOTPs can be found in the band structures of both spin channels in NiZrCl6. NiZrCl6 hosts topologically protected corner states that have a quantized fractional charge (e/3) and are spin-polarized and pinned at the corners of the sample in real space. The SOTP nature in the NiZrCl6 monolayer is resistant to the spin-orbit coupling effect. (ii) Phononic SOTPs can be found in the phonon curves of NiZrCl6. The corner vibrational modes appear inside the frequency gap around 7.98 THz of the NiZrCl6 monolayer, and the secondary topological index can verify the nontrivial phase. The proposed 2D NiZrCl6 material can be a starting point for exploring higher-order topological phases in 2D magnetic and phononic systems

Phononic Weyl pair, phononic Weyl complex, phononic real Chern insulator state, and phononic corner modes in 2D Kekulé-order graphene

The conceptual framework of topological states has recently been extended to bosonic systems, particularly phononic systems. In this work, we chose the recently experimentally prepared two-dimensional (2D) Kekulé-order graphene as a target to propose the coexistence of gapless and gapped topological phonon states in its phonon curves. This is the first work to investigate rich gapped and gapless topological phonon states in experimentally feasible 2D materials. For the gapped topological phonons, 2D Kekulé-order graphene hosts phononic real Chern insulator states, i.e., second-order topological states, and corner vibrational modes inside frequency gaps at 27.96 and 37.065 THz. For the gapless topological phonons, 2D Kekulé-order graphene hosts a phononic Weyl pair [comprising two linear Weyl points (LWPs)] and a phononic Weyl complex [comprising one quadratic nodal point (QNP) and two LWPs] around 7.54 and 47.3 THz (39.2 THz), respectively. Moreover, the difference between the phononic Weyl pair and the phononic Weyl complex was investigated in detail. Our study not only promotes 2D Kekulé-order graphene as a concrete material platform for exploring the intriguing physics of phononic second-order topology but also proposes the coexistence of different categories of Weyl phonons, i.e., a Weyl complex that comprises two LWPs and one QNP, in two dimensions. Our work paves the way for new advancements in topological phononics comprising gapless and gapped topological phonons